The principle of clinical equipoise has been variously characterized by ethicists and clinicians as fundamentally flawed, a myth, and even a moral balm. Yet, the principle continues to be treated as the de facto gold standard for conducting randomized control trials in an ethical manner. Why do we hold on to clinical equipoise, despite its shortcomings being widely known and well-advertised? This paper reviews the most important arguments criticizing clinical equipoise as well as what the most prominent proposed alternatives are. (...) In the process, it evaluates the justification for continuing to use clinical equipoise as the gold standard for randomized control trials. (shrink)

Fredegisus of Tours was an Anglo-Saxon scholar who studied under Alcuin of York and later served at the court of Charlemagne. Although he was apparently well respected by his peers, specific details concerning his life are scarce. His only surviving work is a brief epistle entitled De Nihil et Tenebris. This article provides a new translation of the letter, based on Migne 1851 edition, along with biographical information about its author, a brief critical history of the text, and a (...) commentary on Fredegisus’s significance in the history of Western philosophy. The author argues, against extant critical accounts, that Fredegisus evinces a much higher level of philosophical sophistication than is usually attributed to him. This is evidenced by certain crucial similarities between the De Nihil and Augustine’s De Magistro, as well as the decidedly Platonic overtones of Fredegisus’s doctrine of nothingness. (shrink)

The dominance of Augustine of Hippo in philosophy during the second quarter of the fourteenth century is testified to by three evidences: (1) the wide use of quotations from his works, (2) the flourishing of commentaries on them, especially at Oxford, as reconstructed by William J. Courtenay; (3) the historical-critical treatment of the writings of the Fathers, of the theological and philosophical auctoritates, and of contemporary Scholastic authors at Paris by the Augustinians, as reconstructed by Onorato Grassi. In this article, (...) I focus on the second kind of evidence, taking into account some commentaries on Augustine’s De civitate Dei, namely those of Nicholas Trevet and Thomas Waleys in the English area, and that Francis of Meyronnes in the French area. These commentaries became the basis for Raoul de Presles’s translation of Augustine’s work into Middle French. Moreover, I analyze books 1–5 of Raoul’s translation, showing that it was by no means accidental to his intellectual endeavors and that Raoul employed innovative, Humanist techniques of translation, and shedding light on the comparison of Charles V of France to Charlemagne in the rediscovery of the Augustinian corpus. (shrink)